Dr. Malathy Krishnamurthy

US Patent Agent, PhD (Chemistry)

Email: malathy.kmurthy@davelawgroup.com

Tel: +1 505-695-3113


Summary

Dr. Malathy Krishnamurthy is an interdisciplinary life sciences professional with 15+ years of combined research experience in bioorganic chemistry, molecular biology and synthetic biology.

She is a Technology Transfer and Inventions Specialist in the area of life sciences with experience in drafting, negotiating and executing federal technology transfer agreements with universities, private sector entities and Government agencies.

She is a U.S. Patent and Trademark Office (USPTO) registered patent agent.


Work Experience

U. S. Army Medical Research Institute of Infectious Diseases (USAMRIID), Frederick, MD, Sep 2017 to Present

Project Manager/ Technology Transfer and Inventions Specialist

Provide project management for federal technology transfer agreements and invention disclosures/patent-related projects in support of the Office of Research and Technology Applications (ORTA).

Initiate and participate in the negotiation of federal technology transfer agreements including Cooperative Research and Development Agreements (CRADA), Material Transfer Agreements (MTA) and Confidential Disclosure Agreements (CDA) with universities, private sector entities and Interagency Agreements (IAA) with U.S. Government agencies (e.g. FDA, NIH).

Provide guidance to scientific staff on agreement projects, patent matters and Department of Army (DA) invention disclosures for patentability review.

National Research Council (NRC) Senior Research Associate, U. S. Army Medical Research Institute of Infectious Diseases (USAMRIID), Frederick, MD, Sep 2017 to Jan 2019

Recipient of NRC fellowship for the development of novel synthetic biology tools to counter bacterial antibiotic resistance. Successfully designed and implemented assays for understanding the antibacterial mechanism of antibiotic-small molecule combination against antibiotic resistant bacterial pathogens.

Los Alamos National Laboratory, Los Alamos, NM, May 2013 to Oct 2015

Postdoctoral Research Associate

Developed novel and modular Ribonucleic Acid (RNA) based panel of gene switches (riboregulators) in support of a Department of Energy (DOE) funded program to alter metabolic flux in engineered bacteria for production of bioproducts.

Investigated and validated methods for directed evolution of riboregulators and site-specific recombination methods for chromosomal integration of riboregulators in E. coli.

New Mexico Consortium, Los Alamos, NM, Sep 2011 - May 2013

Associate Research Scientist

Developed genetic engineering tools for improving photosynthetic carbon fixation in microalgae (Chlamydomonas reinhardtii) and C3 plants (Arabidopsis thaliana).

Biocon- Bristol-Myers Squibb Research Center (BBRC), Bangalore, India, Oct 2010 - Sep 2011

Research Investigator

Designed and optimized the synthesis of macrocyclic peptide libraries for delivery of products to Bristol-Myers Squibb (BMS), NJ.

University of Michigan, Ann Arbor, MI, Jun 2008 - Oct 2010

Michigan Chemistry Fellow

Recipient of Michigan Chemistry Fellowship for the investigation of eukaryotic transcriptional machinery proteins using unnatural amino acid mutagenesis in baker’s yeast.


Professional Highlights

National Research Council (NRC) Research Associateship Award, USAMRIID 2015 - 2019

Research Mentor, DoD Science & Engineering Apprenticeship Program, USAMRIID 2016 - 2017

Author highlight for ACS Synthetic Biology publication: “Tunable Riboregulator Switches for Post-transcriptional Control of Gene Expression” 2015

Michigan Chemistry Fellowship Award, University of Michigan 2008 - 2010

Chevez T. Walling Graduate Award for Outstanding Thesis Work, University of Utah 2008

Merit Scholarship in Chemistry, Indian Institute of Technology, India 2000 - 2002

University Rank Holder, Chemistry, University of Madras, India 2000


Education

University of Utah, Salt Lake City, UT, USA 2008
Ph.D. (Chemistry)

Indian Institute of Technology, Chennai, India 2002
M.S. (Chemistry)

University of Madras, Chennai, India 2000
B.S. (Chemistry)

U.S. Patent and Trademark Office (USPTO) registered patent agent (registration # 76,088)

Certification in Advanced Studies in Technology Transfer, Foundation for Advanced Education in the Sciences (FAES), National Institutes of Health 2018


External Publications

Malathy Krishnamurthy, Margaret M. Lemmon, Evan M. Falcinelli, Reuel A. Sandy, Jennifer N. Dootz, Tiffany M. Mott, Sathish Rajamani, Kurt E. Schaecher, Allen J. Duplantier, Rekha G. Panchal. Enhancing the Antibacterial Activity of Polymyxins using a Nonantibiotic Drug. Infection and Drug Resistance (2019), 12, 1393–1405.

Malathy Krishnamurthy, Richard T. Moore, Sathish Rajamani and Rekha G. Panchal. Bacterial Genome Engineering and Synthetic Biology: Combating Pathogens. Review Article, BMC Microbiology (2016), 16, 258.

Malathy Krishnamurthy, Scott P. Hennelly, Taraka Dale, Shawn R. Starkenburg, Ricardo Marti-Arbona, David. T. Fox, Karissa Y. Sanbonmatsu and Clifford J. Unkefer. Tunable Riboregulator Switches for Post-transcriptional Control of Gene Expression. ACS Syn. Biol. (2015), 4, 1326-1334.

Malathy Krishnamurthy, Amanda Dugan, Adaora Nwokoye, Yik-Hong Fung, Jody K. Lancia Chinmay Y. Majmudar and Anna K Mapp. Caught in the Act: Covalent Crosslinking Captures Activator-Coactivator Interactions In Vivo. ACS Chem. Biol. (2011), 6, 1321-1326.

Diana K. Morales, Nicholas J. Jacobs, Sathish Rajamani, Malathy Krishnamurthy, Juan R Cubillos-Ruiz, and Deborah A. Hogan. Antifungal Mechanisms by which a Novel Pseudomonas aeruginosa Phenazine Toxin Kills Candida albicans in Biofilms. Mol. Microbiology (2010), 78, 1379-1392.

Nicole T. Schirle, Rena A. Goodman, Malathy Krishnamurthy, Selective Inhibition of ADAR2-Catalyzed Editing of theSerotonin 2c Receptor pre-mRNA by a Helix-threading Peptide. Org. Biomol. Chem. (2010), 8, 4898-4904.

Malathy Krishnamurthy, Nicole Schirle and Peter A. Beal, Screening Helix-threading Peptides for RNA Binding Using a Thiazole Orange Displacement Assay. Bioorg. Med. Chem. Lett. (2008), 16, 8914-8921.

Malathy Krishnamurthy, Kristina Simon, Anita M. Orendt and Peter A. Beal, Macrocyclic Helix-threading Peptides for Targeting RNA. Angew. Chem. Int. Ed. (2007), 46, 7044-7047.

Malathy Krishnamurthy, Barry D. Gooch and Peter A. Beal, RNA Binding and Thiolytic Stability of a Quinoline-containing Helix-threading Peptide. Org. Biomol. Chem. (2006), 4, 639-645.

Barry D. Gooch, Malathy Krishnamurthy, Mohammad Shadid and Peter A. Beal, Binding of Helix-threading Peptides to E. coli 16S Ribosomal RNA and Inhibition of the S15-16S complex. ChemBioChem. (2005), 6, 2247-2254.

Malathy Krishnamurthy, Barry D. Gooch and Peter A. Beal, Peptide Quinoline Conjugates: A New Class of RNA Binding Molecules. Org. Lett. (2004), 6, 63-66.